Scaling-up Potentially Runaway Systems Using Calorimetry
Neutralization Reactions Case Study
Program Overview
- Scale-up of neutralization reaction using pure calorimetric approach
- Experimental validation
- Kinetics
- Simulation at full plant scale
Within this presentation, simple correlations concerning the possibility of scaling-up a potentially runaway process from laboratory to full plant were proposed and validated using reaction calorimetry.
Particularly, two different scales were analyzed experimentally: 100 mL and 1 L scale, using respectively an EasyMax 102 and an OptiMax 1001 automated synthesis workstations. Then, a simulation of a nine cubic meters scale was carried out using Dynochem software. Results showed a good degree of reliability and suggested the possibility of using fruitfully such correlations for scale-up purposes.
About the Presenter
Sabrina Copelli, PhD
Associate Professor, University of Insubria
Eng. Sabrina Copelli carries out her scientific research activity in various sectors typical of Applied Physics Chemistry and Chemical Engineering, such as kinetics of chemical reactions, modeling of chemical reactors, thermo-chemical stability of reacting mixtures, industrial safety, safe optimization and engineering of polymerization reactions, process intensification of discontinuous synthesis (that is, the use of continuous reactors in order to carry out synthesis which were previously done in discontinuous reactors – ref. to pharmaceutical industry), study of dust explosions, and problems of pollution of exhausted air and waste water. The common matrix of these activities is the study, through a combined approach of experimentation at the laboratory (or pilot plant) scale and mathematical modeling, of the chemical and physical phenomena characteristic of each area, all investigable using the proper tools of Chemical Engineering.
